Iancu, Emanuela M Corthesy, Patricia Baumgaertner, Petra Devevre, Estelle Voelter, Verena Romero, Pedro Speiser, Daniel E Rufer, Nathalie
Published in
Journal of immunology (Baltimore, Md. : 1950)
Protection from reactivation of persistent herpes virus infection is mediated by Ag-specific CD8 T cell responses, which are highly regulated by still poorly understood mechanisms. In this study, we analyzed differentiation and clonotypic dynamics of EBV- and CMV-specific T cells from healthy adults. Although these T lymphocytes included all subset...
Gary-Gouy, Hélène Harriague, Julie Dalloul, Ali Emmanuel Donnadieu Bismuth, Georges
Published in
The Journal of Immunology
CD5 is a cell surface receptor that negatively regulates B cell function, but whose relationship to the immunoreceptor tyrosine-based inhibitory motif (ITIM) family of B cell inhibitory receptors is unclear. Using Fcgamma type IIB receptor-CD5 chimeras encompassing the cytoplasmic domain of CD5, we previously showed that a particular region of the ...
Campos, Regis A Szczepanik, Marian Lisbonne, Mariette Itakura, Atsuko Maria Leite-De-Moraes Askenase, Philip W
Published in
The Journal of Immunology
In cutaneous contact sensitivity there is an early elicited innate cascade of complement, mast cells, and platelets activated via IgM Abs. This response is required to initiate the elicitation of acquired classical contact sensitivity by leading to local recruitment of effector T cells. We recently performed in vivo experiments showing that collabo...
Diana, Julien Moura, Ivan C Vaugier, Céline Gestin, Aurélie Tissandie, Emilie Beaudoin, Lucie Corthésy, Blaise Hocini, Hakim Agnès Lehuen Monteiro, Renato C
...
Published in
The Journal of Immunology
IgA plays ambivalent roles in the immune system. The balance between inhibitory and activating responses relies on the multimerization status of IgA and interaction with their cognate receptors. In mucosal sites, secretory IgA (SIgA) protects the host through immune-exclusion mechanisms, but its function in the bloodstream remains unknown. Using bo...
Laloux, Véronique Beaudoin, Lucie Ronet, Catherine Agnès Lehuen
Published in
The Journal of Immunology
NKT cells are considered unconventional T cells. First, they are restricted by a nonclassical MHC class I molecule, CD1d, which presents glycolipids; second, their TCR repertoire is very limited. After stimulation by their TCR, NKT cells rapidly release large amounts of cytokines, such as IL-4 and IFN-gamma. Little is known about NKT cells present ...
Firat, Elke Huai, Jisen Loredana Saveanu Gaedicke, Simone Aichele, Peter Eichmann, Klaus Peter Van Endert Niedermann, Gabriele
Published in
The Journal of Immunology
Tripeptidyl peptidase II (TPPII) is an oligopeptidase forming giant complexes in the cytosol that have high exo-, but also, endoproteolytic activity. Immunohistochemically, the complexes appear as distinct foci in the cytosol. In part controversial biochemical and functional studies have suggested that TPPII contributes, on the one hand, positively...
Blanchard, Nicolas Lankar, Danielle Faure, Florence Regnault, Armelle Dumont, Céline Raposo, Graça Claire Hivroz
Published in
The Journal of Immunology
We show in this study that human T cells purified from peripheral blood, T cell clones, and Jurkat T cells release microvesicles in the culture medium. These microvesicles have a diameter of 50-100 nm, are delimited by a lipidic bilayer membrane, and bear TCR beta, CD3epsilon, and zeta. This microvesicle production is regulated because it is highly...
Lochner, Matthias Bérard, Marion Sawa, Shinichiro Hauer, Siona Gaboriau-Routhiau, Valérie Fernandez, Tahia Diana Snel, Johannes Bousso, Philippe Nadine Cerf-Bensussan Eberl, Gérard
...
Published in
The Journal of Immunology
Retinoic acid-related orphan receptor (ROR)γt(+) TCRαβ(+) cells expressing IL-17, termed Th17 cells, are most abundant in the intestinal lamina propria. Symbiotic microbiota are required for the generation of Th17 cells, but the requirement for microbiota-derived Ag is not documented. In this study, we show that normal numbers of Th17 cells develop...
Ben Ahmed, Mélika Belhadj Hmida, Nadia Moes, Nicolette Buyse, Sophie Abdeladhim, Maha Louzir, Hechmi Nadine Cerf-Bensussan
Published in
The Journal of Immunology
IL-15 drives chronic inflammation in several human diseases. We have recently shown that IL-15 inhibits the immunosuppressive effects of TGF-beta through blockage of the Smad3-signaling pathway. Data pointing to reciprocal interactions between TGF-beta and CD4(+) regulatory T cells led us to investigate the impact of IL-15 on the de novo generation...
Blanchard, Nicolas Decraene, Maud Yang, Kun Miro-Mur, Francesc Amigorena, Sebastian Claire Hivroz
Published in
The Journal of Immunology
The exact function of TCR clustering and organized macromolecular patterns at the immune synapse between APCs and T lymphocytes is unclear. Using human immature or mature dendritic cells (DCs) and autologous CD4(+) effector T cells, we demonstrate that, within a given conjugate, mature DCs induce strong and long-lasting TCR clustering and protein k...
