Amiot, Aurelien Setakhr, Vida Seksik, Philippe Matthieu Allez Treton, Xavier De Vos, Martine Laharie, David Colombel, Jean-Frederic Abitbol, Vered Reimund, Jean Marie
...
Published in
The American Journal of Gastroenterology
Objectives: Although anti-tumor necrosis factor (TNF) therapy is the treatment of choice for perianal fistulizing Crohn's disease (CD), the efficacy and safety of anti-TNF therapy in enterocutaneous fistula (ECF) remains unclear.
Methods: Between January 2008 and December 2009, we retrospectively reviewed the outcomes of all CD patients with ECF...
Begue, Bernadette Verdier, Julien Frédéric Rieux-Laucat Goulet, Olivier Morali, Alain Canioni, Danielle Jean-Pierre Hugot Daussy, Cécile Verkarre, Virginie Pigneur, Bénédicte
...
Published in
The American Journal of Gastroenterology
Impaired IL10 signaling characterizes a subgroup of IBD patients, whereas the majority of children with severe IBD including EO forms normally produces and responds to IL10. Defective IL22 signaling may additionally impair intestinal epithelial clearance. Our data point out the complexity of IBD, which represent a group of distinct diseases with se...
Barret, Maximilien Malamut, Georgia Rahmi, Gabriel Samaha, Elia Edery, Joël Verkarre, Virginie Elizabeth Macintyre Lenain, Emilie Chatellier, Gilles Nadine Cerf-Bensussan
...
Published in
The American Journal of Gastroenterology
Objectives: Capsule endoscopy (CE) allows for the assessment of the small bowel in numerous intestinal diseases, including celiac disease (CD). The main advantage of CE is the complete visualization of the intestinal mucosal surface. The objective of this study was to investigate whether CE can predict the severity of CD and detect complications.
...
Hmida, Nadia Belhadj Ben Ahmed, Mélika Moussa, Amel Rejeb, Majd Ben Said, Yosra Kourda, Nadia Meresse, Bertrand Abdeladhim, Maha Louzir, Hechmi Nadine Cerf-Bensussan
...
Published in
The American Journal of Gastroenterology
Objectives: Regulatory T cells (Tregs) are instrumental for tolerance to self-antigens and dietary proteins. We have previously shown that interleukin (IL)-15, a cytokine overexpressed in the intestine of patients with celiac disease (CD), does not impair the generation of functional Tregs but renders human T cells resistant to Treg suppression. Tr...
Cellier, Christophe Cervoni, Jean Paul Patey, Natacha Leborgne, Michèle Marteau, Philippe Landi, Bruno Nadine Cerf-Bensussan Barbier, Jean-Philippe Brousse, Nicole
Published in
The American Journal of Gastroenterology
Objective: An increase in the number of intraepithelial lymphocytes (IEL) in the rectal epithelium of patients with active celiac disease has been described. No data are available about how they vary during a gluten-free diet. The aim of the study was to assess the effect of a gluten-free diet on T-cell activation in the rectal mucosa of adult pati...
Matthieu Allez Lemann, Marc Bonnet, Joëlle Cattan, Pierre Jian, Raymond Modigliani, Robert
Published in
The American Journal of Gastroenterology
Objective: Prediction of the clinical course of Crohn's disease (CD) is difficult in the long term. Our aim was to determine whether the presence of severe endoscopic lesions (SELs) may predict a higher risk of colectomy and penetrating complications.
Methods: All patients at our institution with active ileocoIonic CD who had colonoscopies betwe...
Malamut, Georgia Verkarre, Virginie Suarez, Felipe Viallard, Jean-François Lascaux, Anne-Sophie Cosnes, Jacques Bouhnik, Yoram Lambotte, Olivier Béchade, Dominique Ziol, Marianne
...
Published in
The American Journal of Gastroenterology
Objectives: The enteropathy associated with common variable immunodeficiency (CVID) is poorly characterized, and its possible relationships with well-defined causes of enteropathy, such as celiac sprue (CS), remain debated. We aimed to assess the clinical and histopathological features of the enteropathy associated with CVID.
Methods: The medica...
Rochette, Jacques Capron, Dominique Capron, Jean-Pierre Cécile Julier
Published in
The American Journal of Gastroenterology
Fumery, Mathurin Seksik, Philippe Auzolle, Claire Munoz-Bongrand, Nicolas Gornet, Jean-Marc Boschetti, Gilles Cotte, Eddy Buisson, Anthony Dubois, Anne Pariente, Benjamin
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Published in
The American Journal of Gastroenterology
Objectives: We sought to determine the frequency of and risk factors for early (30-day) postoperative complications after ileocecal resection in a well-characterized, prospective cohort of Crohn's disease patients.
Methods: The REMIND group performed a nationwide study in 9 French university medical centers. Clinical-, biological-, surgical-, an...
