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A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers

Coureuil, Mathieu Lécuyer, Hervé Sandrine Bourdoulous Xavier Nassif

Published in Nature Reviews Microbiology

The blood–brain barrier, which is one of the tightest barriers in the body, protects the brain from insults, such as infections. Indeed, only a few of the numerous blood-borne bacteria can cross the blood–brain barrier to cause meningitis. In this Review, we focus on invasive extracellular pathogens, such as Neisseria meningitidis, Streptococcus pn...

Fungi as a promising tool for bioremediation of soils contaminated with aromatic amines, a major class of pollutants. PDF available through Get Fulltext Research

Philippe Silar Dairou, Julien Cocaign, Angélique Busi, Florent Fernando Rodrigues-Lima Jean-Marie Dupret

Published in Nature Reviews Microbiology

Breaking the wall: targeting of the endothelium by pathogenic bacteria.

Lemichez, Emmanuel Lecuit, Marc Xavier Nassif Sandrine Bourdoulous

Published in Nature Reviews Microbiology

The endothelium lining blood and lymphatic vessels is a key barrier separating body fluids from host tissues and is a major target of pathogenic bacteria. Endothelial cells are actively involved in host responses to infectious agents, producing inflammatory cytokines, controlling coagulation cascades and regulating leukocyte trafficking. In this Re...

Viral apoptotic mimicry. PDF available through Get Fulltext Research

Ali Amara Mercer, Jason

Published in Nature Reviews Microbiology

As opportunistic pathogens, viruses have evolved many elegant strategies to manipulate host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the exposure of phosphatidylserine - a marker for apoptosis - on the pathogen surface, is emerging as a common theme used by enveloped viruses to promote infection. Focusing on t...

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