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Hypothalamic regulation of energy balance: a key role for DICER miRNA processing in arcuate POMC neurons.

Cansell, Celine Serge Luquet

Published in Molecular Metabolism

During the last several decades, the world has witnessed a pandemic expansion of pathologies related to high-fat and high-carbohydrate diets including obesity, diabetes, dyslipidemia, and cardiovascular diseases—collectively referred to as metabolic syndrome. Obesity is now considered by the World Health Organization (WHO) to be a worldwide epidemi...

Intestinal invalidation of the glucose transporter GLUT2 delays tissue distribution of glucose and reveals an unexpected...

Schmitt, Charlotte C. Aranias, Thomas Viel, Thomas Chateau, Danielle Le Gall, Maude Waligora-Dupriet, Anne-Judith Melchior, Chloé Rouxel, Ophélie Kapel, Nathalie Gourcerol, Guillaume ...

Published in Molecular Metabolism

Objective Intestinal glucose absorption is orchestrated by specialized glucose transporters such as SGLT1 and GLUT2. However, the role of GLUT2 in the regulation of glucose absorption remains to be fully elucidated. Methods We wanted to evaluate the role of GLUT2 on glucose absorption and glucose homeostasis after intestinal-specific deletion ...

Hippocampal lipoprotein lipase regulates energy balance in rodents

Picard, Alexandre Rouch, Claude Kassis, Nadim Moullé, Valentine S. Croizier, Sophie Denis, Raphaël G. Castel, Julien Coant, Nicolas Davis, Kathryn Clegg, Deborah J. ...

Published in Molecular Metabolism

Brain lipid sensing is necessary to regulate energy balance. Lipoprotein lipase (LPL) may play a role in this process. We tested if hippocampal LPL regulated energy homeostasis in rodents by specifically attenuating LPL activity in the hippocampus of rats and mice, either by infusing a pharmacological inhibitor (tyloxapol), or using a genetic appro...

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