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Clinical and molecular characteristics of squamous cell carcinomas from Fanconi anemia patients.

van Zeeburg, Hester J T Snijders, Peter J F Wu, Thijs Gluckman, Eliane Jean Soulier Surralles, Jordi Castella, Maria van der Wal, Jacqueline E Wennerberg, Johan Califano, Joseph ...

Published in Journal of the National Cancer Institute

Fanconi anemia is a recessively inherited disease that is characterized by congenital abnormalities, bone marrow failure, and a predisposition to develop cancer, particularly squamous cell carcinomas (SCCs) in the head and neck and anogenital regions. Previous studies of Fanconi anemia SCCs, mainly from US patients, revealed the presence of high-ri...

Presynaptic calcium stores and synaptic transmission.

Thibault Collin Alain Marty Isabel Llano

Published in Journal of the National Cancer Institute

Following the gradual recognition of the importance of intracellular calcium stores for somatodendritic signaling in the mammalian brain, recent reports have also indicated a significant role of presynaptic calcium stores. Ryanodine-sensitive stores generate local, random calcium signals that shape spontaneous transmitter release. They amplify spik...

Eye movements in reading isolated words: evidence for strong biases towards the center of the screen.

Vitu, Françoise Zoi Kapoula Lancelin, Denis Lavigne, Frédéric

Published in Journal of the National Cancer Institute

Three experiments were conducted that compared the eye movement pattern to a peripheral word or letter string as a function of the position of an initial fixation stimulus relative to the center of the screen and the straight-ahead position. Results revealed a strong bias of the eye behavior towards the center of the screen, but not towards the str...

Criteria interactions across visual attributes.

Andrei Gorea Caetta, Florent Sagi, Dov

Published in Journal of the National Cancer Institute

Judgmental interference in dual tasks has been demonstrated in conditions where the detection or discrimination of different contrast increments applied to two stimuli presented simultaneously or in sequence. The present work demonstrates such interference for changes along two distinct visual features, namely contrast and orientation, when simulta...

Kids Enter the MATCH

Gudrun Schleiermacher Olivier Delattre

Published in Journal of the National Cancer Institute

Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study.

Demenais, F Mohamdi, H Chaudru, V Goldstein, A M Newton Bishop, J A Bishop, D T Kanetsky, P A Hayward, N K Gillanders, E Elder, D E ...

Published in Journal of the National Cancer Institute

Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, inv...

Latency of saccades, vergence, and combined movements in children with early onset convergent or divergent strabismus.

Bucci, Maria Pia Zoi Kapoula Yang, Qing Brémond-Gignac, Dominique

Published in Journal of the National Cancer Institute

The goal of this study was to examine latency of horizontal eye movements in the natural space (saccades, vergence, and combined saccade-vergence movements) in children with early onset convergent or divergent strabismus. Ten children were tested (8-11 years old): three with divergent strabismus, seven with convergent strabismus. A paradigm was use...

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