Université Sorbonne Paris Cité (USPC) - Sciences Exactes et Technologie (SET) & Sciences de la Vie et de la Santé (SVS)

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Osteogenic protein 1 does not stimulate a regenerative effect in cultured human degenerated nucleus pulposus tissue.

van Dijk, Bart G M Esther Potier van Dijk, Maarten Creemers, Laura B Ito, Keita

Published in Journal of Tissue Engineering and Regenerative Medicine

Low back pain is a major cause of disability and is heavily associated with intervertebral disc degeneration. Osteogenic protein 1 (OP-1) is a growth factor that has shown potential to regenerate the intervertebral disc in human cells and animal models. However, high doses are required, presumably due to clearance from the tissue; controlled releas...

Desferrioxamine-driven upregulation of angiogenic factor expression by human bone marrow stromal cells.

Esther Potier Ferreira, Elisabeth Dennler, Sylviane Mauviel, Alain Oudina, Karim Delphine Logeart-Avramoglou Hervé Petite

Published in Journal of Tissue Engineering and Regenerative Medicine

Bone marrow stromal cells (BMSCs) are the subject of intense research because of their biological properties and potential use for the repair of damaged tissues. Success of BMSC-based therapies, however, relies on a number of methodological improvements, including the establishment of a vascular network providing nutrients and oxygen to the transpl...

Comparative study of the osteogenic ability of four different ceramic constructs in an ectopic large animal model.

Viateau, Véronique Manassero, Mathieu Sensébé, Luc Langonné, Alain Marchat, David Delphine Logeart-Avramoglou Hervé Petite Morad Bensidhoum

Published in Journal of Tissue Engineering and Regenerative Medicine

Tissue-engineered constructs combining bone marrow mesenchymal stem cells with biodegradable osteoconductive scaffolds are very promising for repairing large segmental bone defects. Synchronizing and controlling the balance between scaffold-material resorption and new bone tissue formation are crucial aspects for the success of bone tissue engineer...

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