Renaud Dentin Tomas-Cobos, Lidia Fabienne Foufelle Leopold, Jane Girard, Jean Catherine Postic Pascal Ferre
Published in
Journal of Hepatology
BACKGROUND & AIMS:
In liver, the glucose-responsive transcription factor ChREBP plays a critical role in converting excess carbohydrates into triglycerides through de novo lipogenesis. Although the importance of ChREBP in glucose sensing and hepatic energy utilization is strongly supported, the mechanism driving its activation in response to gluco...
Taïeb, Julien Delarche, Charlotte Valérie Paradis Mathurin, Philippe Grenier, Alain Crestani, Bruno Dehoux, Monique Thabut, Dominique Gougerot-Pocidalo, Marie-Anne Poynard, Thierry
...
Published in
Journal of Hepatology
These findings suggest that, by releasing HGF, PMN could participate in liver regeneration during severe alcoholic hepatitis.
Torre, Cyril Benhamouche, Samira Mitchell, Claudia Godard, Cécile Veber, Philippe Franck Letourneur Cagnard, Nicolas Jacques, Sébastien Finzi, Laetitia Christine Perret
...
Published in
Journal of Hepatology
Background & aims: β-Catenin is an oncogene frequently mutated in hepatocellular carcinoma. In this study, we investigated target genes of β-catenin signaling in hepatocyte proliferation.
Methods: We studied transgenic mice displaying either inactivation or activation of the β-catenin pathway, focusing on analysis of liver proliferation due to a...
Alfaro, Maite Larrea, Esther Prieto, Jesús Kramer, M Gabriela Zabala, Maider Lasarte, Juan José Christine Perret Sola, Josu Berraondo, Pedro
Published in
Journal of Hepatology
Although long-term induction of IL-12 expression in the liver can inhibit HCC growth, the efficacy of the treatment appears to be limited by the activation of immunosuppressive mechanisms.
Vedrenne, Vanessa Galmiche, Louise Chretien, Dominique de Lonlay, Pascale Munnich, Arnold Agnès Rötig
Published in
Journal of Hepatology
Background & aims: Multiple respiratory chain deficiencies represent a common cause of mitochondrial diseases and often result in hepatic failure. A significant fraction of patients present mitochondrial DNA depletion but a number of cases remain unexplained. The aim of our study was to identify the disease causing gene in a kindred with intrauteri...
Renous, Reginald Sophie Caillat-Zucman Debray, Dominique Alvarez, Fernando Djilali-Saiah, Idriss
Published in
Journal of Hepatology
Background/aims: Susceptibility HLA class II alleles associated with autoimmune hepatitis (AIH) were only described in case-control studies.
Methods: The transmission/disequilibrium test was used in 50 simplex families with AIH, to determine if affected offspring received the disease-associated allele more frequently than its alternate. HLA-DRB1...
Fucho, Raquel Martínez, Laura Baulies, Anna Torres, Sandra Tarrats, Nuria Fernandez, Anna Ribas, Vicente Astudillo, Alma M Balsinde, Jesús Garcia-Rovés, Pablo
...
Published in
Journal of Hepatology
These findings underscore a critical role for ASMase in diet-induced NASH and suggest the potential of amitriptyline as a treatment for patients with NASH.
Djilali-Saiah, Idriss Fakhfakh, Amin Louafi, Hamida Sophie Caillat-Zucman Debray, Dominique Alvarez, Fernando
Published in
Journal of Hepatology
Background/aims: Type 2 autoimmune hepatitis (AIH) is characterized by the presence of anti-liver kidney microsome (anti-LKM-1) and/or anti-liver cytosol type 1 (anti-LC1) autoantibodies. However, the correlation between these autoantibodies and the genetic background has not been studied.
Methods: Frequencies of HLA class II alleles were compar...
Vaquero, Javier Guedj, Nathalie Clapéron, Audrey Ho-Bouldoires, Thanh Huong Nguyen Valérie Paradis Fouassier, Laura
Published in
Journal of Hepatology
Cholangiocarcinoma (CCA) is an aggressive tumor with a poor prognosis due to its late clinical presentation and the lack of effective non-surgical therapies. Unfortunately, most of the patients are not eligible for curative surgery owing to the presence of metastases at the time of diagnosis. Therefore, it is important to understand the steps leadi...
Nouët, Yann Dahan, Jennifer Labalette, Charlotte Levillayer, Florence Julien, Boris Jouvion, Grégory Cairo, Stefano Vives, Francina Langa Ribeiro, Agnès Huerre, Michel
...
Published in
Journal of Hepatology
Background & Aims
The four and a half LIM-only protein 2 (FHL2) is upregulated in diverse pathological conditions. Here, we analyzed the effects of FHL2 overexpression in the liver of FHL2 transgenic mice ( Apo-FHL2).
Methods
We first examined cell proliferation and apoptosis in Apo-FHL2 livers and performed partial hepatectomy to investigate hi...
