Alliouachene, Samira Tuttle, Robyn L Boumard, Stephanie Lapointe, Thomas Berissi, Sophie Germain, Stephane Jaubert, Francis Tosh, David Birnbaum, Morris J Pende, Mario
...
Published in
Journal of Clinical Investigation
Factors that promote pancreatic beta cell growth and function are potential therapeutic targets for diabetes mellitus. In mice, genetic experiments suggest that signaling cascades initiated by insulin and IGFs positively regulate beta cell mass and insulin secretion. Akt and S6 kinase (S6K) family members are activated as part of these signaling ca...
Cavadini, Patrizia Vermi, William Facchetti, Fabio Fontana, Stefania Nagafuchi, Seiho Mazzolari, Evelina Sediva, Anna Marrella, Veronica Villa, Anna Fischer, Alain
...
Published in
Br J Dermatol
Omenn syndrome is a severe primary immunodeficiency with putative autoimmune manifestations of the skin and gastrointestinal tract. The disease is caused by hypomorphic mutations in recombination-activating genes that impair but do not abolish the process of VDJ recombination, leading to the generation of autoreactive T cells with a highly restrict...
Moshous, Despina Pannetier, Christophe Chasseval Rd, Régina de Deist Fl, Françoise le Cavazzana-Calvo, Marina Romana, Serge Macintyre, Elizabeth Canioni, Danielle Brousse, Nicole Fischer, Alain
...
Published in
Br J Dermatol
We have previously described the identification of Artemis, a factor involved in the nonhomologous end joining (NHEJ) phase of V(D)J recombination of T and B cell receptor genes. Null mutations of the Artemis gene result in a complete absence of T and B lymphocytes that is associated with increased cell radiosensitivity, causing the radiosensitive ...
Lebras, Morgane Deniaud, Aurelien Brenner, Catherine Bren, Gary D Morin, Mario Y Phenix, Barbara N Dong, Li Jiang, Susan X Sim, Valerie L Zurakowski, Bogdan
...
Published in
Br J Dermatol
Inhibitors of HIV protease have been shown to have antiapoptotic effects in vitro, yet whether these effects are seen in vivo remains controversial. In this study, we have evaluated the impact of the HIV protease inhibitor (PI) nelfinavir, boosted with ritonavir, in models of nonviral disease associated with excessive apoptosis. In mice with Fas-in...
Jenkins, R Gisli Su, Xiao Su, George Scotton, Christopher J Camerer, Eric Laurent, Geoffrey J Davis, George E Chambers, Rachel C Matthay, Michael A Sheppard, Dean
...
Published in
Br J Dermatol
Activation of latent TGF-beta by the alpha(v)beta6 integrin is a critical step in the development of acute lung injury. However, the mechanism by which alpha(v)beta6-mediated TGF-beta activation is regulated has not been identified. We show that thrombin, and other agonists of protease-activated receptor 1 (PAR1), activate TGF-beta in an alpha(v)be...
Chatenoud, Lucienne Bach, Jean-François
Published in
Br J Dermatol
It is now well established that a distinct subset of T lymphocytes is essential for downregulating immune responses to both endogenous (self) and exogenous antigens. These Tregs are CD4+ and express high levels of CD25 (the alpha chain of the IL-2 receptor) and the transcription factor Foxp3. The mechanisms determining the lifespan, homeostasis, an...
Bonduelle, Olivia Carrat, Fabrice Luyt, Charles-Edouard Leport, Catherine Mosnier, Anne Benhabiles, Nora Krivine, Anne Rozenberg, Flore Yahia, Nora Samri, Assia
...
Published in
Journal of Clinical Investigation
The magnitude, quality, and maintenance of immunological memory after infection or vaccination must be considered for future design of effective influenza vaccines. In 2009, the influenza pandemic produced disease that ranged from mild to severe, even fatal, illness in infected healthy adults and led to vaccination of a portion of the population wi...
Jambou, Florence Zhang, Wei Menestrier, Monique Klingel-Schmitt, Isabelle Michel, Olivier Caillat-Zucman, Sophie Aissaoui, Abderrahim Landemarre, Ludovic Berrih-Aknin, Sonia Cohen-Kaminsky, Sylvia
...
Published in
Br J Dermatol
Serum anti-T cell receptor (TCR) Ab's are involved in immune regulation directed against pathogenic T cells in experimental models of autoimmune diseases. Our identification of a dominant T cell population expressing the Vbeta5.1 TCR gene (TCRBV5-1), which is responsible for the production of pathogenic anti-acetylcholine receptor (AChR) autoantibo...
Thébault-Baumont, Karine Dubois-Laforgue, Danielle Krief, Patricia Briand, Jean-Paul Halbout, Philippe Vallon-Geoffroy, Karine Morin, Joëlle Laloux, Véronique Lehuen, Agnès Carel, Jean-Claude
...
Published in
Br J Dermatol
Accumulating evidence favors a role for proinsulin as a key autoantigen in diabetes. In the mouse, two proinsulin isoforms coexist. Most studies point to proinsulin 2 as the major isoform recognized by T cells in the NOD mouse. We studied mice in which a null proinsulin 2 mutation was transferred from proinsulin 2-deficient 129 mice onto the NOD ba...
Viollet, Benoit Andreelli, Fabrizio Jørgensen, Sebastian B Perrin, Christophe Geloen, Alain Flamez, Daisy Mu, James Lenzner, Claudia Baud, Olivier Bennoun, Myriam
...
Published in
Br J Dermatol
AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid metabolism. To better understand the physiological role of AMPK, we generated a knockout mouse model in which the AMPKalpha2 catalytic subunit gene was inactivated. AMPKalpha2(-/-) mice presented high glucose levels in the fed period and during an oral glucose chal...
