Dumas, Audrey Lê-Bury, Gabrielle Marie-Anaïs, Florence Herit, Floriane Mazzolini, Julie Guilbert, Thomas Pierre Bourdoncle Russell, David G. Serge Benichou Zahraoui, Ahmed
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Published in
Journal of Cell Biology
Human immunodeficiency virus type 1 (HIV-1) impairs major functions of macrophages but the molecular basis for this defect remains poorly characterized. Here, we show that macrophages infected with HIV-1 were unable to respond efficiently to phagocytic triggers and to clear bacteria. The maturation of phagosomes, defined by the presence of late end...
Schatton, Désirée Pla-Martin, David Marx, Marie-Charlotte Hansen, Henriette Mourier, Arnaud Ivan Nemazanyy Pessia, Alberto Zentis, Peter Corona, Teresa Kondylis, Vangelis
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Published in
Journal of Cell Biology
Mitochondria are essential organelles that host crucial metabolic pathways and produce adenosine triphosphate. The mitochondrial proteome is heterogeneous among tissues and can dynamically change in response to different metabolic conditions. Although the transcriptional programs that govern mitochondrial biogenesis and respiratory function are wel...
Amara, Ali Littman, Dan R
Published in
Journal of Cell Biology
To efficiently bud off from infected cells, HIV and other enveloped viruses hijack the host cellular machinery that is normally involved in vacuolar protein sorting and multivesicular body (MVB) biogenesis. The HIV Gag protein mimics hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs), a modular adaptor protein that links membrane ca...
Goudin, Nicolas Kurowska, Mathieu Madera-Salcedo, Iris Karina Huang, Jian-Dong Alain Fischer González-Espinosa, Claudia De Saint Basile, Geneviève Blank, Ulrich Ménasché, Gaël Munoz, Isabelle
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Published in
Journal of Cell Biology
Cross-linking of mast cell IgE receptors (FcRI) triggers degranulation of secretory granules (SGs) and the release of many allergic and inflammatory mediators. Although degranulation depends crucially on microtubule dynamics, the molecular machinery that couples SGs to microtubule-dependent transport is poorly understood. Here, we demonstrate that ...
