Nguyen, Thi Thu Nga Rato, Sylvie Molina, Jean-Michel François Clavel Delaugerre, Constance Fabrizio Mammano
Published in
Journal of Antimicrobial Chemotherapy
The emergence of different resistance mutations in patients was in full agreement with the impact of mutations in different baseline integrase contexts. Evolution towards different resistance genotypes is thus largely determined by the capacity of different integrase sequences present at baseline to minimize the effect of mutations on virus RC whil...
Gantner, Pierre Assoumou, Lambert Leruez-Ville, Marianne David, Ludivine Suzan-Monti, Marie Costagliola, Dominique Christine Rouzioux Ghosn, Jade Evarist Anrs Ep Study Group,
Published in
Journal of Antimicrobial Chemotherapy
Objectives: Intermittent seminal HIV-RNA detection can occur in MSM despite concomitant plasma virological control on combined ART (cART). We undertook the present study to determine if seminal HIV detection was associated with seminal cytomegalovirus (CMV) detection or detection of HIV-infected cells in semen.
Methods: Longitudinal semen sample...
Slama, Laurence Landman, Roland Assoumou, Lambert Benalycherif, Aida Samri, Assia Joly, Véronique Pialoux, Gilles Valin, Nadia Cabié, André Duvivier, Claudine
...
Published in
Journal of Antimicrobial Chemotherapy
Objectives: Boosted PIs are commonly prescribed in patients presenting with advanced HIV infection. We assessed the efficacy and tolerability of once-daily ritonavir-boosted atazanavir or darunavir plus two NRTIs in HIV-1-infected ART-naive patients with severe immunosuppression, targeting at least an 85% success rate at week 48.
Methods: This 4...
Schou, Kenneth B. Mogensen, Johanne B. Morthorst, Stine K. Nielsen, Brian S. Aleliunaite, Aiste Serra-Marques, Andrea Fürstenberg, Nicoline Sophie Saunier Bizet, Albane A. Veland, Iben R.
...
Published in
Journal of Antimicrobial Chemotherapy
Ciliary membrane composition is controlled by transition zone (TZ) proteins such as RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse signalling systems like the Sonic hedgehog (Shh) pathway. Activation of this pathway involves Shh-induced ciliary accumulation of Smoothened (SMO), which is disrupted by disease-causing...
Goemaere, Emilie Melet, Armelle Larue, Valéry Lieutaud, Aurélie Alves De Sousa, Rodolphe Chevalier, Jacqueline Yimga-Djapa, Liselotte Giglione, Carmela Huguet, Florian Alimi, Mickael
...
Published in
Journal of Antimicrobial Chemotherapy
OBJECTIVES: Bacterial drug resistance is a worrying public health problem and there is an urgent need for research and development to provide new antibacterial molecules. Peptide deformylase (PDF) is now a well-described intracellular target selected for the design of a new antibiotic group, PDF inhibitors (PDFIs). The initial bacterial susceptibil...
