Barbault, Florent Ren, Bo Rebehmed, Joseph Teixeira, Catia Luo, Yun Smila-Castro, Ornella François Maurel Fan, BoTao Zhang, Liangren Zhang, Lihe
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Published in
European Journal of Medicinal Chemistry
Ribonucleic acids (RNAs) have only recently been viewed as a target for small-molecules drug discovery. Aminoglycoside compounds are antibiotics which bind the ribosomal A site (16S fragment) and cause misreading of the bacterial genetic code and inhibit translocation. In this work, a complete molecular modeling study is done for 16 newly derived a...
Allam, Anas Maigre, Laure Alves de Sousa, Rodolphe Dumont, Estelle Vergalli, Julia Pagès, Jean-Marie Isabelle Artaud
Published in
European Journal of Medicinal Chemistry
Structure of bacterial envelope is one of the major factors contributing to Gram negative bacterial resistance. To develop new agents that target the bacterial membranes, we synthesized, by analogy with our previous peptide conjugates, new amphiphilic 3′,4′,6-trinaphthylmethylene neamines functionalized at position 5 through a short spacer by a che...
