Université Sorbonne Paris Cité (USPC) - Sciences Exactes et Technologie (SET) & Sciences de la Vie et de la Santé (SVS)
  • Upload

  • Se connecter

  • S'inscrire

Chercher sur MyScienceWork
News Publications Membres Événements

Recherche de publications

Sort by
  • Relevance
  • Published Date

Flexible computational docking studies of new aminoglycosides targeting RNA 16S bacterial ribosome site.

Barbault, Florent Ren, Bo Rebehmed, Joseph Teixeira, Catia Luo, Yun Smila-Castro, Ornella François Maurel Fan, BoTao Zhang, Liangren Zhang, Lihe ...

Published in European Journal of Medicinal Chemistry

Ribonucleic acids (RNAs) have only recently been viewed as a target for small-molecules drug discovery. Aminoglycoside compounds are antibiotics which bind the ribosomal A site (16S fragment) and cause misreading of the bacterial genetic code and inhibit translocation. In this work, a complete molecular modeling study is done for 16 newly derived a...

New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria

Allam, Anas Maigre, Laure Alves de Sousa, Rodolphe Dumont, Estelle Vergalli, Julia Pagès, Jean-Marie Isabelle Artaud

Published in European Journal of Medicinal Chemistry

Structure of bacterial envelope is one of the major factors contributing to Gram negative bacterial resistance. To develop new agents that target the bacterial membranes, we synthesized, by analogy with our previous peptide conjugates, new amphiphilic 3′,4′,6-trinaphthylmethylene neamines functionalized at position 5 through a short spacer by a che...

Powered by Polaris
  • A propos de l'USPC
  • FAQ