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Autoreactive antibody repertoire is perturbed in atherosclerotic patients.

Caligiuri, Giuseppina Stahl, Dorothea Kaveri, Srini Irinopoulous, Théano Savoie, Françoise Mandet, Chantal Vandaele, Marta Kazatchkine, Michel D Michel, Jean-Baptiste Antonino Nicoletti ...

Published in Diabetes care

In patients with clinical symptoms of coronary atherosclerosis, T cells are activated and directed to autologous proteins contained in the active plaques, suggesting that autoimmune responses may play a role in atherosclerosis progression. Organ-specific autoimmune diseases are sometimes accompanied by broad alterations of serum autoreactive antibo...

A personalized approach to optimize hepatitis B treatment in treatment-naive patients.

Patrick Marcellin Liang, Jake

Published in Diabetes care

In a treatment-naive patient with chronic hepatitis B, a personalized approach allows treatment efficacy to be optimized. Firstly, the selection of good candidates for therapy is crucial. Patients with chronic active hepatitis B--with relatively low levels of HBV DNA replication (

Vascular endothelial growth factor-A is expressed both on lymphoma cells and endothelial cells in angioimmunoblastic T-c...

Zhao, Wei-Li Mourah, Samia Mounier, Nicolas Leboeuf, Christophe Daneshpouy, Marjan Ertault Legrès, Luc Meignin, Veronique Eric Oksenhendler Maignin, Christine Le Calvo, Fabien ...

Published in Diabetes care

Vascular endothelial growth factor-A (VEGF-A), a main stimulator of endothelial cell proliferation, plays an important role on tumor angiogenesis. Angioimmunoblastic T-cell lymphoma (AITL) show the most prominent vascular component among lymphomas and their prognosis is difficult to predict. To assess the clinical significance of VEGF-A in AITL, VE...

Characterization of drug resistance in antiretroviral-treated patients infected with HIV-1 CRF02_AG and AGK subtypes in ...

Sylla, Mohamed Chamberland, Annie Catherine Boileau Traoré, Hamar A Ag-Aboubacrine, Souleyman Cissé, Mamadou Koala, Samual Drabo, Joseph Diallo, Ismael Niamba, Pascal ...

Published in Diabetes care

Although CRFO2_AG is the dominant clade in the Burkina Faso/Mali region, isolates with subtype K reverse transcriptase were frequent in our cohort. Drug resistance mutation pathways in subtype K reverse transcriptase need to be further evaluated in a larger cohort of non-B HIV-infected individuals.

Vascular endothelial growth factor VEGF189 induces human neutrophil chemotaxis in extravascular tissue via an autocrine ...

Ancelin, Magali Chollet-Martin, Sylvie Hervé, Marie Astrid Legrand, Chantal Jamel El Benna Perrot-Applanat, Martine

Published in Diabetes care

Vascular endothelial growth factor (VEGF) is a potent and specific endothelial cell mitogen involved in normal and pathological angiogenesis. Our group recently reported that, among the several VEGF isoforms, VEGF189 (V189) is selectively induced in decidual endometrial cells during the mid-late phase of the menstrual cycle, together with polymorph...

Prognostic factors for virological response in antiretroviral therapy-naive patients in the MONARK Trial randomized to r...

Flandre, Philippe Delaugerre, Constance Ghosn, Jade Chaix, Marie Laure Horban, Andrzej Girard, Pierre-Marie Gladysz, Andrzej Cohen-Codar, Isabelle Van, Philippe Ngo Taburet, Anne-Marie ...

Published in Diabetes care

HIV-1 RNA measured at baseline or at week 4 and HIV-1 subtype (B versus non-B) were independent predictive factors of VR in patients starting therapy with LPV/r alone. Although based on a small sample size, results of this study showed that adherence to therapy is lower in patients harbouring non-B subtypes and appears to be a key factor of VR in t...

Sustained virological response after 14-day treatment with danoprevir and 48-week treatment with pegylated interferon-α2...

Larrey, Dominique Carenco, Christophe Guyader, Dominique Boyer, Nathalie Benhamou, Yves Pageaux, Georges-Philippe Rouzier, Regine Marcellin, Patrick

Published in Diabetes care

The addition of danoprevir for 14 days to PEG-IFN/RBV treatment results in a high SVR rate in HCV genotype 1 treatment-naive patients.

A population analysis of weight-related differences in lopinavir pharmacokinetics and possible consequences for protease...

Bouillon-Pichault, Marion Jullien, Vincent Piketty, Christophe Viard, Jean-Paul Morini, Jean-Pierre Chhun, Stéphanie Krivine, Anne Salmon, Dominique Dupin, Nicolas Weiss, Laurence ...

Published in Diabetes care

These results support lopinavir therapeutic drug monitoring and the use of higher lopinavir doses for PI-pretreated patients.

New functional domains of human cytomegalovirus pUL89 predicted by sequence analysis and three-dimensional modelling of ...

Champier, Gaël Hantz, Sébastien Couvreux, Anthony Stuppfler, Stéphanie Mazeron, Marie-Christine Bouaziz, Serge Denis, François Alain, Sophie

Published in Diabetes care

To better understand HCMV DNA maturation and the mechanism of action of benzimidazole derivatives, we studied the HCMV pUL89 protein by a genetic approach combined with primary structure analysis. The pUL89 sequence analysis of 25 HCMV strains and counterparts among herpesviruses allowed identification of 12 conserved regions. We also built a three...

Conserved domains and structure prediction of human cytomegalovirus UL27 protein.

Hantz, Sébastien Couvreux, Anthony Champier, Gaël Trapes, Laurène Cotin, Sébastien Denis, François Bouaziz, Serge Alain, Sophie

Published in Diabetes care

Although the function of pUL27 is still unknown in the HCMV replication cycle, our approach identified target domains that appeared to be essential to the function of pUL27. This work provides a better understanding on the relative importance of each pUL27 mutation and could form the basis of later comparison analyses, when a three-dimensional stru...

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