Dam, Elisabeth Lebel-Binay, Sophie Rochas, Séverine Thibaut, Laurent Faudon, Jean-Louis Thomas, Claire-Marie Essioux, Laurent Hill, Andrew Schutz, Malte François Clavel
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Published in
Diabetes care
We hypothesize that differences between the PIs in intracellular protein-binding behaviour or inhibition of drug transporters (P glycoprotein, MDR1 and MDR2) could result in intracellular levels of saquinavir being increased by co-administration with lopinavir or atazanavir. The effect of this increase would be masked in cases involving viruses tha...
Caligiuri, Giuseppina Stahl, Dorothea Kaveri, Srini Irinopoulous, Théano Savoie, Françoise Mandet, Chantal Vandaele, Marta Kazatchkine, Michel D Michel, Jean-Baptiste Antonino Nicoletti
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Published in
Diabetes care
In patients with clinical symptoms of coronary atherosclerosis, T cells are activated and directed to autologous proteins contained in the active plaques, suggesting that autoimmune responses may play a role in atherosclerosis progression. Organ-specific autoimmune diseases are sometimes accompanied by broad alterations of serum autoreactive antibo...
Brun-Vézinet, Françoise Costagliola, Dominique Khaled, Mounir Ait Calvez, Vincent François Clavel Clotet, Bonaventura Haubrich, Richard Kempf, Dale King, Marty Kuritzkes, Daniel
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Published in
Diabetes care
Whereas previously the output of HIV resistance tests has been based on therapeutically arbitrary criteria, there is now an ongoing move towards correlating test interpretation with virological outcomes on treatment. This approach is undeniably superior, in principle, for tests intended to guide drug choices. However the predictive accuracy of a gi...
Patrick Marcellin Liang, Jake
Published in
Diabetes care
In a treatment-naive patient with chronic hepatitis B, a personalized approach allows treatment efficacy to be optimized. Firstly, the selection of good candidates for therapy is crucial. Patients with chronic active hepatitis B--with relatively low levels of HBV DNA replication (
Zhao, Wei-Li Mourah, Samia Mounier, Nicolas Leboeuf, Christophe Daneshpouy, Marjan Ertault Legrès, Luc Meignin, Veronique Eric Oksenhendler Maignin, Christine Le Calvo, Fabien
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Published in
Diabetes care
Vascular endothelial growth factor-A (VEGF-A), a main stimulator of endothelial cell proliferation, plays an important role on tumor angiogenesis. Angioimmunoblastic T-cell lymphoma (AITL) show the most prominent vascular component among lymphomas and their prognosis is difficult to predict. To assess the clinical significance of VEGF-A in AITL, VE...
Sylla, Mohamed Chamberland, Annie Catherine Boileau Traoré, Hamar A Ag-Aboubacrine, Souleyman Cissé, Mamadou Koala, Samual Drabo, Joseph Diallo, Ismael Niamba, Pascal
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Published in
Diabetes care
Although CRFO2_AG is the dominant clade in the Burkina Faso/Mali region, isolates with subtype K reverse transcriptase were frequent in our cohort. Drug resistance mutation pathways in subtype K reverse transcriptase need to be further evaluated in a larger cohort of non-B HIV-infected individuals.
Ancelin, Magali Chollet-Martin, Sylvie Hervé, Marie Astrid Legrand, Chantal Jamel El Benna Perrot-Applanat, Martine
Published in
Diabetes care
Vascular endothelial growth factor (VEGF) is a potent and specific endothelial cell mitogen involved in normal and pathological angiogenesis. Our group recently reported that, among the several VEGF isoforms, VEGF189 (V189) is selectively induced in decidual endometrial cells during the mid-late phase of the menstrual cycle, together with polymorph...
Flandre, Philippe Delaugerre, Constance Ghosn, Jade Chaix, Marie Laure Horban, Andrzej Girard, Pierre-Marie Gladysz, Andrzej Cohen-Codar, Isabelle Van, Philippe Ngo Taburet, Anne-Marie
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Published in
Diabetes care
HIV-1 RNA measured at baseline or at week 4 and HIV-1 subtype (B versus non-B) were independent predictive factors of VR in patients starting therapy with LPV/r alone. Although based on a small sample size, results of this study showed that adherence to therapy is lower in patients harbouring non-B subtypes and appears to be a key factor of VR in t...
Larrey, Dominique Carenco, Christophe Guyader, Dominique Boyer, Nathalie Benhamou, Yves Pageaux, Georges-Philippe Rouzier, Regine Marcellin, Patrick
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Diabetes care
The addition of danoprevir for 14 days to PEG-IFN/RBV treatment results in a high SVR rate in HCV genotype 1 treatment-naive patients.
Chaix, Marie-Laure Desquilbet, Loic Descamps, Diane Costagliola, Dominique Deveau, Christiane Galimand, Julie Goujard, Cécile Signori-Schmuck, Anne Schneider, Veronique Tamalet, Catherine
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Published in
Diabetes care
In this large cohort of HAART-treated PHI-patients, the presence of drug resistance mutations led to suboptimal response to early therapy.
