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Gene therapy: Myth or reality? PDF available through Get Fulltext Research

Alain Fischer

Published in Comptes Rendus Biologies

Gene therapy has become a reality, although still a fragile one. Clinical benefit has been achieved over the last 17years in a limited number of medical conditions for which pathophysiological studies determined that they were favorable settings. They include inherited disorders of the immune system, leukodystrophies, possibly hemoglobinopathies, h...

High carbohydrate diet induces nonalcoholic steato-hepatitis (NASH) in a desert gerbil PDF available through Get Fulltext Research

Semiane, Nesrine Fabienne Foufelle Pascal Ferre Hainault, Isabelle Ameddah, Souad Mallek, Aicha Khalkhal, Ali Dahmani, Yasmina

Published in Comptes Rendus Biologies

A high intake of sugars has been linked to diet-induced health problems. The aim of this study was to assess whether the long-term consumption of a high-carbohydrate diet (HCD) would cause the hepatic histopathological and metabolic abnormalities that characterize nonalcoholic steatohepatitis (NASH) in a desert gerbil, Gerbillus gerbillus. Compared...

Progress in the epidemiological understanding of gene-environment interactions in major diseases: cancer.

Clavel, Jacqueline

Published in Psychosom Med

Cancer epidemiology has undergone marked development since the 1950s. One of the most spectacular and specific contributions was the demonstration of the massive effect of smoking on the occurrence of lung, larynx, and bladder cancer. Major chemical, physical, and biological carcinogenic agents have been identified in the working environment and in...

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