Trousse, Françoise Poluch, Sylvie Alessandra Pierani Dutriaux, Annie Bock, Hans H Nagasawa, Takashi Verdier, Jean-Michel Rossel, Mireille
Published in
Cerebral Cortex
Cajal–Retzius (CR) cells are essential for cortical development and lamination. These pioneer neurons arise from distinct progenitor sources, including the cortical hem and the ventral pallium at pallium–subpallium boundary (PSB). CXCR4, the canonical receptor for the chemokine CXCL12, controls the superficial location of hem-derived CR cells. Howe...
Paus, Tomás Bernard, Manon Chakravarty, M Mallar Davey Smith, George Gillis, Jesse Lourdusamy, Anbarasu Melka, Melkaye G Leonard, Gabriel Pavlidis, Paul Perron, Michel
...
Published in
Cerebral Cortex
The most dramatic growth of the human brain occurs in utero and during the first 2 years of postnatal life. Genesis of the cerebral cortex involves cell proliferation, migration, and apoptosis, all of which may be influenced by prenatal environment. Here, we show that variation in KCTD8 (potassium channel tetramerization domain 8) is associated wit...
Roberto Toro Burnod, Yves
Published in
Cerebral Cortex
The convolutions of the mammalian cortex are one of its most intriguing characteristics. Their pattern is very distinctive for different species, and there seems to be a remarkable relationship between convolutions and the architectonic and functional regionalization of the cerebral cortex. Yet the mechanisms behind the development of convolutions ...
Raznahan, Armin Roberto Toro Daly, Eileen Robertson, Dene Murphy, Clodagh Deeley, Quinton Bolton, Patrick F Paus, Tomás Murphy, Declan G M
Published in
Cerebral Cortex
There is increasing evidence that children with autism spectrum disorder (ASD) have age-related differences from controls in cortical volume (CV). It is less clear, however, if these persist in adulthood and whether these reflect alterations in cortical thickness (CT) or cortical surface area (SA). Hence, we used magnetic resonance imaging to inves...
Freret-Hodara, Betty Cui, Yi Griveau, Amélie Vigier, Lisa Arai, Yoko Touboul, Jonathan Alessandra Pierani
Published in
Cerebral Cortex
Loss of neurons in the neocortex is generally thought to result in a final reduction of cerebral volume. Yet, little is known on how the developing cerebral cortex copes with death of early-born neurons. Here, we tackled this issue by taking advantage of a transgenic mouse model in which, from early embryonic stages to mid-corticogenesis, abundant ...
Roberto Toro Fox, Peter T Paus, Tomás
Published in
Cerebral Cortex
Understanding the interactions among different brain regions is fundamental to our understanding of brain function. Here we describe a complete map of functional connections in the human brain derived by an automatic meta-analysis of 825 neuroimaging articles, representing 3402 experiments. The likelihood of a functional connection between regions ...
Roberto Toro Perron, Michel Pike, Bruce Richer, Louis Veillette, Suzanne Pausova, Zdenka Paus, Tomás
Published in
Cerebral Cortex
During evolution, the mammalian cerebral cortex has expanded disproportionately to brain volume. As a consequence, most mammals with large brains have profusely convoluted cortices. The human cortex is a good example of this trend, however, given the large variability in human brain size, it is not clear how cortical folding varies from the smalles...
Roy, Achira Gonzalez-Gomez, Miriam Pierani, Alessandra Meyer, Gundela Tole, Shubha
Published in
Cerebral cortex (New York, N.Y. : 1991)
Early brain development is regulated by the coordinated actions of multiple signaling centers at key boundaries between compartments. Three telencephalic midline structures are in a position to play such roles in forebrain patterning: The cortical hem, the septum, and the thalamic eminence at the diencephalic-telencephalic boundary. These structure...
Friocourt, Gaëlle Koulakoff, Annette Philippe Chafey Boucher, Dominique Fauchereau, Fabien Chelly, Jamel Francis, Fiona
Published in
Cerebral Cortex
Type I lissencephaly is a cortical malformation disorder characterized by disorganized cortical layers and gyral abnormalities and associated with severe cognitive impairment and epilepsy. The exact pathophysiological mechanisms underlying the epilepsy and mental retardation in this and related disorders remain unknown. Two genes, LIS1 and doubleco...
Borello, Ugo Madhavan, Mayur Vilinsky, Ilya Faedo, Andrea Alessandra Pierani Rubenstein, John Campbell, Kenneth
Published in
Cerebral Cortex
To gain new insights into the transcriptional regulation of cortical development, we examined the role of the transcription factor Sp8, which is downstream of Fgf8 signaling and known to promote rostral cortical development. We have used a binary transgenic system to express Sp8 throughout the mouse telencephalon in a temporally restricted manner. ...