Zinzindohoué, Franck Blons, Hélène Hans, Stéphane Loriot, Marie-Anne Houllier, Anne-Marie Brasnu, Daniel Laccourreye, Ollivier Tregouet, David-Alexandre Stucker, Isabelle Pierre Laurent-Puig
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Published in
Cell Stem Cell
Matrix metalloproteinase (MMP) 1 and 3 genes play an important role in initiating tumor growth and promoting cell spread. Since MMP1 and MMP3 transcription levels can be modulated by promoter polymorphism, we investigated the impact of different genotypes on the occurrence of head and neck cancer in a Caucasian case control study. DNA was extracted...
Lorenz, Carmen Lesimple, Pierre Bukowiecki, Raul Zink, Annika Inak, Gizem Mlody, Barbara Singh, Manvendra Semtner, Marcus Mah, Nancy Auré, Karine
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Published in
Cell Stem Cell
Mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases. Modeling of these defects has been difficult because of the challenges associated with engineering mtDNA. We show here that neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) retain the parental mtDNA profile and exhibit a metabolic swi...
Zhang, Haojian Kozono, David E O'Connor, Kevin W Vidal-Cardenas, Sofia Rousseau, Alix Hamilton, Abigail Moreau, Lisa Gaudiano, Emily F Greenberger, Joel Bagby, Grover
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Published in
Cell Stem Cell
Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide shRNA screen in human FA fibroblasts, we identify t...
Comincini, Sergio Facoetti, Angelica Del Vecchio, Igor Peoc'h, Katell Jean-Louis Laplanche Magrassi, Lorenzo Ceroni, Mauro Ferretti, Luca Nano, Rosanna
Published in
Cell Stem Cell
The expression of the prion (PRNP) and prion like-doppel (PRND) genes and the presence of the proteins prion (PrP) and doppel (Dpl) were investigated in human gliomas. The PRNP and PRND expression profiles were evaluated by real-time reverse transcription-quantitative PCR in low- and high-grade astrocytomas, in glioblastoma-derived cell lines and i...
William-Faltaos, Sara Rouillard, Dany Philippe Lechat Bastian, Gérard
Published in
Cell Stem Cell
L-OHP induced cell cycle arrest and moderate apoptosis; these two activities were time-dependent. These findings warrant further investigation into the potential antitumour activity of L-OHP in MCF7 and Hela cells and in lengthening the infusion duration in order to achieve the acquired cellular modifications.
Benjamin G. Cuiffo Antoine Campagne George W. Bell Antonio Lembo Francesca Orso Evan C. Lien Manoj K. Bhasin Monica Raimo Summer E. Hanson Andriy Marusyk
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Published in
Cell Stem Cell
Mesenchymal stem/stromal cells (MSCs) are progenitor cells shown to participate in breast tumor stroma formation and to promote metastasis. Despite expanding knowledge of their contributions to breast malignancy, the underlying molecular responses of breast cancer cells (BCCs) to MSC influences remain incompletely understood. Here, we show that MSC...
Lebeau, Jerome Fouchet, Pierre Ory, Katherine Sylvie Chevillard
Published in
Cell Stem Cell
Steroid hormones have been implicated in the regulation of cellular proliferation and of telomerase activity. Because progestin modulates cell cycle progression in vitro, we investigated if the regulation of telomerase activity by progesterone could be cell cycle-dependent. We found that progesterone treatment of the T47D breast cancer cell line in...
Boyer, Sw Schroeder, Av Smith-Berdan, S Forsberg, Ec
Published in
Cell Stem Cell
While it is clear that a single hematopoietic stem cell (HSC) is capable of giving rise to all other hematopoietic cell types, the differentiation paths beyond HSC remain controversial. Contradictory reports on the lineage potential of progenitor populations have questioned their physiological contribution of progenitor populations to multilineage ...
Bats, Anne-Sophie Blons, Helene Narjoz, Celine Le Frere-Belda, Marie-Aude Pierre Laurent-Puig Lecuru, Fabrice
Published in
Cell Stem Cell
MSI analysis in uterine cavity washings may be a promising screening tool for Lynch syndrome-associated endometrial cancer diagnosis.
Oudard, Stephane Levalois, Cecile Andrieu, Jean-Marie Bougaran, Joelle Validire, Pierre Thiounn, Nicolas Poupon, Marie-France Fourme, Emmanuelle Sylvie Chevillard
Published in
Cell Stem Cell
This study investigated the multidrug resistance, proliferation and apoptosis expression in renal cell carcinomas compared to adjacent normal kidney (ANK) tissues. Multidrug resistance (MDR1), multidrug resistance-associated protein (MRP), glutathione-S-transferase-pi (GST-pi), Topoisomerase-II alpha (TOPO-IIalpha), thymidylate synthase (TS), thymi...
