Auffret, Julien Freemark, Michael Carré, Nadège Mathieu, Yves Cécile Tourrel-Cuzin Lombès, Marc Jamileh Movassat Binart, Nadine
Published in
AJP Endocrinology and Metabolism
Prolactin (PRL) and placental lactogens stimulate β-cell replication and insulin production in pancreatic islets and insulinoma cells through binding to the PRL receptor (PRLR). However, the contribution of PRLR signaling to β-cell ontogeny and function in perinatal life and the effects of the lactogens on adaptive islet growth are poorly understoo...
Begriche, Karima Lettéron, Philippe Abbey-Toby, Adjé Vadrot, Nathalie Robin, Marie-Anne André Bado Pessayre, Dominique Fromenty, Bernard
Published in
AJP Endocrinology and Metabolism
Partial leptin deficiency is not uncommon in the general population. We hypothesized that leptin insufficiency could favor obesity, nonalcoholic steatohepatitis (NASH), and other metabolic abnormalities, particularly under high calorie intake. Thus, mice partially deficient in leptin (ob/+) and their wild-type (+/+) littermates were fed for 4 mo wi...
Lacraz, Grégory Figeac, Florence Jamileh Movassat Kassis, Nadim Portha, Bernard
Published in
AJP Endocrinology and Metabolism
The alteration of the beta-cell population in the Goto-Kakizaki rat (GK/Par line), a model of spontaneous type 2 diabetes, has been ascribed to significantly decreased beta-cell replication and neogenesis, while beta-cell apoptosis is surprisingly not enhanced and remains in the normal range. To gain insight into the mechanisms by which those beta-...
Jørgensen, Sebastian B Treebak, Jonas T Benoit Viollet Schjerling, Peter Sophie Vaulont Wojtaszewski, Jørgen F P Richter, Erik A
Published in
AJP Endocrinology and Metabolism
We investigated the role of AMPKalpha2in basal, exercise training-, and AICAR-induced protein expression of GLUT4, hexokinase II (HKII), mitochondrial markers, and AMPK subunits. This was conducted in red (RG) and white gastrocnemius (WG) muscle from wild-type (WT) and alpha2-knockout (KO) mice after 28 days of activity wheel running or daily AICAR...
Dolz, Manuel Jamileh Movassat Bailbé, Danielle Le Stunff, Hervé Giroix, Marie-Hélène Fradet, Magali Kergoat, Micheline Portha, Bernard
Published in
AJP Endocrinology and Metabolism
cAMP-raising agents with glucagon-like peptide-1 (GLP-1) as the first in class, exhibit multiple actions that are beneficial for the treatment of type 2 diabetic (T2D) patients, including improvement of glucose-induced insulin secretion (GIIS). To gain additional insight into the role of cAMP in the disturbed stimulus-secretion coupling within the ...
Figeac, Florence Uzan, Benjamin Faro, Monique Chelali, Noura Portha, Bernard Jamileh Movassat
Published in
AJP Endocrinology and Metabolism
Wnt/beta-catenin signaling is critical for a variety of fundamental cellular processes. Here, we investigated the implication of the Wnt/beta-catenin signaling in the in vivo regulation of beta-cell growth and regeneration in normal and diabetic rats. To this aim, TCF7L2, the distal effector of the canonical Wnt pathway, was knocked down in groups ...
Moinard, Christophe Le Plénier, Servane Goron, Arthur Athanassia Sotiropoulos Archambault, Eliane Guihenneuc, Chantal Walrand, Stéphane Salles, Jérome Jourdan, Marion Neveux, Nathalie
...
Published in
AJP Endocrinology and Metabolism
Citrulline (CIT) is an endogenous amino acid produced by the intestine. Recent literature has consistently shown CIT to be an activator of muscle protein synthesis (MPS). However, the underlying mechanism is still unknown. Our working hypothesis was that CIT might regulate muscle homeostasis directly through the mTORC1/PI3K/MAPK pathways. Because C...
Jamileh Movassat Bailbé, Danièle Lubrano-Berthelier, Cécile Picarel-Blanchot, Françoise Bertin, Eric Mourot, Jacques Portha, Bernard
Published in
AJP Endocrinology and Metabolism
The adult Goto-Kakizaki (GK) rat is characterized by impaired glucose-induced insulin secretion in vivo and in vitro, decreased beta-cell mass, decreased insulin sensitivity in the liver, and moderate insulin resistance in muscles and adipose tissue. GK rats do not exhibit basal hyperglycemia during the first 3 wk after birth and therefore could be...
Stolarczyk, Emilie Guissard, Christophe Michau, Aurélien Even, Patrick C Grosfeld, Alexandra Serradas, Patricia Lorsignol, Anne Pénicaud, Luc Brot-Laroche, Edith Armelle Leturque
...
Published in
AJP Endocrinology and Metabolism
The sugar transporter GLUT2, present in several tissues of the gut-brain axis, has been reported to be involved in the control of food intake. GLUT2 is a sugar transporter sustaining energy production in the cell, but it can also function as a receptor for extracellular glucose. A glucose-signaling pathway is indeed triggered, independently of gluc...
Erraji-Benchekroun, Loubna Couton, Dominique Catherine Postic Borde, Isabelle Gaston, Jesintha Guillet, Jean-Gérard André, Claudine
Published in
AJP Endocrinology and Metabolism
In the livers of humans and many other mammalian species, beta2-adrenergic receptors (beta2-ARs) play an important role in the modulation of glucose production by glycogenolysis and gluconeogenesis. In male mice and rats, however, the expression and physiological role of hepatic beta2-ARs are rapidly lost with development under normal physiological...
