Université Sorbonne Paris Cité (USPC) - Sciences Exactes et Technologie (SET) & Sciences de la Vie et de la Santé (SVS)
  • Upload

  • Se connecter

  • S'inscrire

Chercher sur MyScienceWork
1 News 33K Publications 664 Membres 3 Événements

Targeting immunoproteasome and glutamine supplementation prevent intestinal hyperpermeability

Ghouzali, Ibtissem Lemaitre, Caroline Bahlouli, Wafa Azhar, Saïda Christine Bole-Feysot Meleine, Mathieu Ducrotté, Philippe Déchelotte, Pierre Coëffier, Moïse

Published in Biochimica et Biophysica Acta (BBA) - General Subjects

Background: Intestinal hyperpermeability has been reported in several intestinal and non-intestinal disorders. We aimed to investigate the role of the ubiquitin proteasome system in gut barrier regulation in two mice models: the water avoidance stress model (WAS) and a post-inflammatory model (post-TNBS). Methods: Both models were applied in C57...

Gene Therapy with Hematopoietic Stem Cells: The Diseased Bone Marrow's Point of View

Marina Cavazzana Ribeil, Jean-Antoine Lagresle-Peyrou, Chantal Isabelle Andre-Schmutz

Published in Stem Cells and Development

When considering inherited diseases that can be treated by gene transfer into hematopoietic stem cells (HSCs), there are only two in which the HSC and progenitor cell distribution inside the bone marrow and its microenvironment are exactly the same as in a healthy subject: metachromatic leukodystrophy (MLD) and adrenoleukodystrophy (ALD). In all ot...

Arterio-venous fistula for Automated Red Blood Cells Exchange in patients with sickle cell disease: Complications and ou... PDF available through Get Fulltext Research

Delville, Marianne Manceau, Sandra Abdallah, N. A. Stolba, Jan Awad, Sameh Damy, Thibaud Gellen, Barnabas Sabbah, Laurent Debbache, Karima Audard, Vincent ...

Published in American Journal of Hematology

Erythrocytapheresis (ER) can improve outcome in patients with sickle cell disease (SCD). A good vascular access is required but frequently it can be difficult to obtain for sickle cell patients. Arterio-venous fistulas (AVFs) have been suggested for ER in SCD supported by limited evidence. We report the largest cohort of ER performed with AVFs from...

Mimicking the Regulation Step of Fe-Monooxygenases: Allosteric Modulation of FeIV-Oxo Formation by Guest Binding in a Di...

Ségaud, Nathalie De Thomasson, Constance Daverat, Caroline Sénéchal-David, Katell Dos Santos, Amandine Steinmetz, Vincent Maître, Philippe Rebilly, Jean-Noël Banse, Frédéric Olivia Reinaud ...

Published in Chemistry - A European Journal

A heteroditopic ligand associated with a calix[6]arene scaffold bearing a tris(imidazole) coordinating site at its small rim and an amine/pyridine ligand at its large rim has been prepared, and its regioselective coordination to ZnII at the small rim and FeII in the amine/pyridine ligand has been achieved. The heterodinuclear complex obtained displ...

De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development

Gordon, Christopher T Xue, Shifeng Yigit, Gökhan Filali, Hicham Ken Chen Rosin, Nadine Yoshiura, Koh-ichiro Oufadem, Myriam Beck, Tamara J McGowan, Ruth ...

Published in Nature Genetics

Bosma arhinia microphthalmia syndrome (BAMS) is an extremely rare and striking condition characterized by complete absence of the nose with or without ocular defects. We report here that missense mutations in the epigenetic regulator SMCHD1 mapping to the extended ATPase domain of the encoded protein cause BAMS in all 14 cases studied. All mutation...

One-month apparent diffusion coefficient correlates with response to radiofrequency ablation of hepatocellular carcinoma... PDF available through Get Fulltext Research

Barat, Maxime Fohlen, Audrey Cassinotto, Christophe Jannot, Anne Sophie Dautry, Raphael Pelage, Jean-Pierre Boudiaf, Mourad Marc Pocard Eveno, Clarisse Taouli, Bachir ...

Published in Journal of Magnetic Resonance Imaging

Purpose To assess whether apparent diffusion coefficient (ADC) values at 1 and 3 months after radiofrequency ablation (RFA) may be associated with a favorable response to therapy for hepatocellular carcinoma (HCC) and liver metastases. Materials and Methods Fifty‐nine patients with HCC (n = 35) or liver metastases (n = 24) who underwent 1.5T d...

The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratificatio... PDF available through Get Fulltext Research

Loth, Eva Charman, Tony Mason, Luke Tillmann, Julian Jones, Emily J H Wooldridge, Caroline Ahmad, Jumana Auyeung, Bonnie Brogna, Claudia Ambrosino, Sara ...

Published in Molecular Autism

Background The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments wi...

A Dual Functional Electroactive and Fluorescent Probe for Coupled Measurements of Vesicular Exocytosis with High Spatial...

Liu, Xiaoqing Savy, Alexandra Maurin, Sylvie Grimaud, Laurence François Darchen Quinton, Damien Eric Labbe Buriez, Olivier Delacotte, Jérôme Lemaître, Frédéric ...

Published in Angewandte Chemie International Edition

In this work, Fluorescent False Neurotransmitter 102 (FFN102), a synthesized analogue of biogenic neurotransmit-ters, was demonstrated to show both pH-dependent fluores-cence and electroactivity. To study secretory behaviors at the single-vesicle level, FFN102 was employed as a new fluores-cent/electroactive dual probe in a coupled technique (amper...

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development ... PDF available through Get Fulltext Research

Manchev, Vladimir T Bouzid, Hind Antony-Debré, Iléana Leite, Betty Meurice, Guillaume Droin, Nathalie Prebet, Thomas Costello, Régis T Vainchenker, William Plo, Isabelle ...

Published in Journal of cellular and molecular medicine

Familial platelet disorder with predisposition to acute myeloid leukaemia (FPD/AML) is characterized by germline RUNX1 mutations, thrombocytopaenia, platelet dysfunction and a risk of developing acute myeloid and in rare cases lymphoid T leukaemia. Here, we focus on a case of a man with a familial history of RUNX1R174Q mutation who developed at the...

First-principles investigation of the structural and electronic properties of self-assemblies of functional molecules on...

Quesne-Turin, Ambroise Touzeau, Jeremy Dappe, Yannick Diawara, Boubakar François Maurel Seydou, Mahamadou

Graphene-based two-dimensional materials have attracted an increasing attention these last years. Among them, the system formed by molecular adsorption on, aim of modifying the conductivity of graphene and make it semiconducting, is of particular interest. We use here hierarchical first-principles simulations to investigate the energetic and electr...

  • ← Previous
  • 1
  • …
  • 5
  • 6
  • 7 (current)
  • 8
  • 9
  • …
  • 100
  • Next →
Powered by Polaris
  • A propos de l'USPC
  • FAQ