Université Sorbonne Paris Cité (USPC) - Sciences Exactes et Technologie (SET) & Sciences de la Vie et de la Santé (SVS)
  • Upload

  • Se connecter

  • S'inscrire

Chercher sur MyScienceWork
1 News 33K Publications 664 Membres 3 Événements

Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus ... PDF available through Get Fulltext Research

Izawa, Kazushi Martin, Emmanuel Soudais, Claire Bruneau, Julie Boutboul, David Rodriguez, Rémy Lenoir, Christelle Hislop, Andrew D Besson, Caroline Touzot, Fabien ...

Published in The Journal of experimental medicine

Epstein-Barr virus (EBV) infection in humans is a major trigger of malignant and nonmalignant B cell proliferations. CD27 is a co-stimulatory molecule of T cells, and inherited CD27 deficiency is characterized by high susceptibility to EBV infection, though the underlying pathological mechanisms have not yet been identified. In this study, we repor...

Autoimmune and inflammatory manifestations occur frequently in primary immunodeficiencies

Alain Fischer Provot, Johan Jais, Jean-Philippe Alcais, Alexandre Mahlaoui, Nizar members of the, Ceredih French P. I. D. ...

Published in Journal of Allergy and Clinical Immunology

Background: Primary immunodeficiencies (PIDs) are inherited diseases associated with a considerable increase in susceptibility to infections. It is known that PIDs can also predispose to cancer and immune diseases, including allergy, autoimmunity, and inflammation. Objective: We aimed at determining the incidence of autoimmunity and inflammation...

Intestinal invalidation of the glucose transporter GLUT2 delays tissue distribution of glucose and reveals an unexpected... PDF available through Get Fulltext Research

Schmitt, Charlotte C. Aranias, Thomas Viel, Thomas Chateau, Danielle Le Gall, Maude Waligora-Dupriet, Anne-Judith Melchior, Chloé Rouxel, Ophélie Kapel, Nathalie Gourcerol, Guillaume ...

Published in Molecular Metabolism

Objective Intestinal glucose absorption is orchestrated by specialized glucose transporters such as SGLT1 and GLUT2. However, the role of GLUT2 in the regulation of glucose absorption remains to be fully elucidated. Methods We wanted to evaluate the role of GLUT2 on glucose absorption and glucose homeostasis after intestinal-specific deletion ...

HMCan-diff: a method to detect changes in histone modifications in cells with different genetic characteristics PDF available through Get Fulltext Research

Ashoor, Haitham Louis-Brennetot, Caroline Janoueix-Lerosey, Isabelle Bajic, Vladimir B. Valentina Boeva

Published in Nucleic Acids Research

Comparing histone modification profiles between cancer and normal states, or across different tumor samples, can provide insights into understanding cancer initiation, progression and response to therapy. ChIP-seq histone modification data of cancer samples are distorted by copy number variation innate to any cancer cell. We present HMCan-diff, the...

Postoperative Complications after Ileocecal Resection in Crohn's Disease: A Prospective Study From the REMIND Group

Fumery, Mathurin Seksik, Philippe Auzolle, Claire Munoz-Bongrand, Nicolas Gornet, Jean-Marc Boschetti, Gilles Cotte, Eddy Buisson, Anthony Dubois, Anne Pariente, Benjamin ...

Published in The American Journal of Gastroenterology

Objectives: We sought to determine the frequency of and risk factors for early (30-day) postoperative complications after ileocecal resection in a well-characterized, prospective cohort of Crohn's disease patients. Methods: The REMIND group performed a nationwide study in 9 French university medical centers. Clinical-, biological-, surgical-, an...

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders PDF available through Get Fulltext Research

Lorenz, Carmen Lesimple, Pierre Bukowiecki, Raul Zink, Annika Inak, Gizem Mlody, Barbara Singh, Manvendra Semtner, Marcus Mah, Nancy Auré, Karine ...

Published in Cell Stem Cell

Mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases. Modeling of these defects has been difficult because of the challenges associated with engineering mtDNA. We show here that neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) retain the parental mtDNA profile and exhibit a metabolic swi...

Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus

Wilson, Jayne Louise Frédéric Bouillaud Almeida, Ana S. Vieira, Helena L. Ouidja, Mohand Ouidir Dubois-Randé, Jean-Luc Foresti, Roberta Motterlini, Roberto

Published in Free Radical Biology and Medicine

Microglia fulfill important immunological functions in the brain by responding to pathological stresses and modulating their activities according to pro- or anti-inflammatory stimuli. Recent evidence indicates that changes in metabolism accompany the switch in microglia activation state, favoring glycolysis over oxidative phosphorylation when cells...

HK2 Recruitment to Phospho-BAD Prevents Its Degradation, Promoting Warburg Glycolysis by Theileria-Transformed Leukocyte...

Haidar, Malak Anne Lombes Frédéric Bouillaud Kennedy, Eileen J. Gordon Langsley

Published in ACS Infectious Diseases

Theileria annulata infects bovine leukocytes, transforming them into invasive, cancer-like cells that cause the widespread disease called tropical theileriosis. We report that in Theileria-transformed leukocytes hexokinase-2 (HK2) binds to B cell lymphoma-2-associated death promoter (BAD) only when serine (S) 155 in BAD is phosphorylated. We show t...

Broadening the phenotypic spectrum of POP1-skeletal dysplasias: identification of POP1 mutations in a mild and severe sk...

Barraza-García, J. Rivera-Pedroza, C.I. Hisado-Oliva, A. Belinchón-Martínez, A. Sentchordi-Montané, L. Duncan, E.L. Clark, G.R. del Pozo, A. Ibáñez-Garikano, K. Offiah, A. ...

Published in Clinical Genetics

Processing of Precursor 1 (POP1) is a large protein common to the ribonuclease-mitochondrial RNA processing (RNase-MRP) and RNase-P (RMRP) endoribonucleoprotein complexes. Although its precise function is unknown, it appears to participate in the assembly or stability of both complexes. Numerous RMRP mutations have been reported in individuals with...

Spherocytic shift of red blood cells during storage provides a quantitative whole cell-based marker of the storage lesio...

Roussel, Camille Dussiot, Michaël Marin, Mickaël Morel, Alexandre Ndour, Papa Alioune Duez, Julien Caroline Le Van Kim Olivier Hermine Colin, Yves A. Buffet P, ...

Published in Transfusion

Background: Storage lesion may explain the rapid clearance of up to 25% of transfused red blood cells (RBCs) in recipients. Several alterations affect stored RBC but a quantitative, whole cell-based predictor of transfusion yield is lacking. Because RBCs with reduced surface area are retained by the spleen, we quantified changes in RBC dimensions d...

  • ← Previous
  • 1
  • 2
  • 3
  • 4 (current)
  • 5
  • 6
  • …
  • 100
  • Next →
Powered by Polaris
  • A propos de l'USPC
  • FAQ