Université Sorbonne Paris Cité (USPC) - Sciences Exactes et Technologie (SET) & Sciences de la Vie et de la Santé (SVS)
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Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus

Wilson, Jayne Louise Frédéric Bouillaud Almeida, Ana S. Vieira, Helena L. Ouidja, Mohand Ouidir Dubois-Randé, Jean-Luc Foresti, Roberta Motterlini, Roberto

Published in Free Radical Biology and Medicine

Microglia fulfill important immunological functions in the brain by responding to pathological stresses and modulating their activities according to pro- or anti-inflammatory stimuli. Recent evidence indicates that changes in metabolism accompany the switch in microglia activation state, favoring glycolysis over oxidative phosphorylation when cells...

HK2 Recruitment to Phospho-BAD Prevents Its Degradation, Promoting Warburg Glycolysis by Theileria-Transformed Leukocyte...

Haidar, Malak Anne Lombes Frédéric Bouillaud Kennedy, Eileen J. Gordon Langsley

Published in ACS Infectious Diseases

Theileria annulata infects bovine leukocytes, transforming them into invasive, cancer-like cells that cause the widespread disease called tropical theileriosis. We report that in Theileria-transformed leukocytes hexokinase-2 (HK2) binds to B cell lymphoma-2-associated death promoter (BAD) only when serine (S) 155 in BAD is phosphorylated. We show t...

Spherocytic shift of red blood cells during storage provides a quantitative whole cell-based marker of the storage lesio...

Roussel, Camille Dussiot, Michaël Marin, Mickaël Morel, Alexandre Ndour, Papa Alioune Duez, Julien Caroline Le Van Kim Olivier Hermine Colin, Yves A. Buffet P, ...

Published in Transfusion

Background: Storage lesion may explain the rapid clearance of up to 25% of transfused red blood cells (RBCs) in recipients. Several alterations affect stored RBC but a quantitative, whole cell-based predictor of transfusion yield is lacking. Because RBCs with reduced surface area are retained by the spleen, we quantified changes in RBC dimensions d...

New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria

Allam, Anas Maigre, Laure Alves de Sousa, Rodolphe Dumont, Estelle Vergalli, Julia Pagès, Jean-Marie Isabelle Artaud

Published in European Journal of Medicinal Chemistry

Structure of bacterial envelope is one of the major factors contributing to Gram negative bacterial resistance. To develop new agents that target the bacterial membranes, we synthesized, by analogy with our previous peptide conjugates, new amphiphilic 3′,4′,6-trinaphthylmethylene neamines functionalized at position 5 through a short spacer by a che...

Recombinant overexpression of camel hepcidin cDNA in Pichia pastoris: purification and characterization of the polyHis-t...

Mohamed Boumaiza Chahed, Haifa Ezzine, Aymen Jaouan, Maryse Gianoncelli, Alessandra Longhi, Giovanna Carmona, Fernando Arosio, Paolo Marie-Agnès Sari Marzouki, Mohamed Nejib ...

Published in Journal of Molecular Recognition

Hepcidin, a liver‐expressed antimicrobial peptide, has been demonstrated to act as an iron regulatory hormone as well as to exert a wide spectrum of antimicrobial activity. The aim of this work was the expression, as secreted peptide, purification, and characterization of a new recombinant polyHis‐tagged camel hepcidin (HepcD‐His) in yeast Pichia p...

One-Anastomosis Gastric Bypass: Why Biliary Reflux Remains Controversial?

Bruzzi, Matthieu Jean-Marc Chevallier Czernichow, Sébastien

Published in Bull Acad Natl Med

One-anastomosis gastric bypass is an alternative to the “gold-standard” Roux-en-Y gastric bypass. This technique appears to be safe and efficient, but controversy remains regarding the long-term theoretical risk of subsequent biliary reflux and its possible complications, such as cancer. The aim of the present narrative review was to summarize some...

Extracellular vesicles in coronary artery disease

Chantal Boulanger Loyer, Xavier Rautou, Pierre-Emmanuel Amabile, Nicolas

Published in Nature Reviews Cardiology

Membrane vesicles released in the extracellular space are composed of a lipid bilayer enclosing soluble cytosolic material and nuclear components. Extracellular vesicles include apoptotic bodies, exosomes, and microvesicles (also known previously as microparticles). Originating from different subcellular compartments, the role of extracellular vesi...

A Prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis

Bissonnette, Julien Altamirano, José Devue, Cécile Roux, Olivier Payancé, Audrey Lebrec, Didier Bedossa, Pierre Valla, Dominique Durand, François Ait Oufella, H. ...

Published in Hepatology

The diagnosis of alcoholic hepatitis (AH) often requires a transjugular liver biopsy (TJLB), a procedure that is not always readily accessible. We analyzed plasma biomarkers to estimate the presence of histological features of AH among patients with clinical suspicion of AH. Using enzyme‐linked immunosorbent assay, we tested M65 and M30 (circulatin...

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

Poisson, Johanne Lemoinne, Sara Chantal Boulanger Durand, François Richard Moreau Valla, Dominique Rautou, Pierre-Emmanuel

Published in Journal of Hepatology

Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells representing the interface between blood cells on the one side and hepatocytes and hepatic stellate cells on the other side. LSECs represent a permeable barrier. Indeed, the association of 'fenestrae', absence of diaphragm and lack of basement membrane make them the...

Mutations in sphingosine-1-phosphase lyase cause nephrosis with ichthyosis and adrenal insufficiency

Lovric, Svjetlana Goncalves, Sara Gee, Heon Yung Oskouian, Babak Srinivas, Honnappa Choi, Won-Il Shril, Shirlee Ashraf, Shazia Tan, Weizhen Rao, Jia ...

Published in Journal of Clinical Investigation

Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease cases. A mutation in 1 of over 40 monogenic genes can be detected in approximately 30% of individuals with SRNS whose symptoms manifest before 25 years of age. However, in many patients, the genetic etiology remains unknown. Here, we have performed whole exome sequenci...

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