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Numerical Study of Double-Layered Microchannel Heat Sinks with Different Cross-Sectional Shapes. PDF available through Get Fulltext Research

Deng, Daxiang Pi, Guang Zhang, Weixun Wang, Peng Fu, Ting

Published in Entropy (Basel, Switzerland)

This work numerically studies the thermal and hydraulic performance of double-layered microchannel heat sinks (DL-MCHS) for their application in the cooling of high heat flux microelectronic devices. The superiority of double-layered microchannel heat sinks was assessed by a comparison with a single-layered microchannel heat sink (SL-MCHS) with the...

New functional domains of human cytomegalovirus pUL89 predicted by sequence analysis and three-dimensional modelling of ...

Champier, Gaël Hantz, Sébastien Couvreux, Anthony Stuppfler, Stéphanie Mazeron, Marie-Christine Bouaziz, Serge Denis, François Alain, Sophie

Published in Diabetes care

To better understand HCMV DNA maturation and the mechanism of action of benzimidazole derivatives, we studied the HCMV pUL89 protein by a genetic approach combined with primary structure analysis. The pUL89 sequence analysis of 25 HCMV strains and counterparts among herpesviruses allowed identification of 12 conserved regions. We also built a three...

Conserved domains and structure prediction of human cytomegalovirus UL27 protein.

Hantz, Sébastien Couvreux, Anthony Champier, Gaël Trapes, Laurène Cotin, Sébastien Denis, François Bouaziz, Serge Alain, Sophie

Published in Diabetes care

Although the function of pUL27 is still unknown in the HCMV replication cycle, our approach identified target domains that appeared to be essential to the function of pUL27. This work provides a better understanding on the relative importance of each pUL27 mutation and could form the basis of later comparison analyses, when a three-dimensional stru...

The 3-O-(3',3'-dimethylsuccinyl) derivative of betulinic acid (DSB) inhibits the assembly of virus-like particles in HIV...

Boulanger, Pierre DaFonseca, Sandrina Blommaert, Armand Coric, Pascale Hong, Saw See Bouaziz, Serge

Published in Diabetes care

Sequence alignment and three-dimensional modelling by homology of the CA-SP1-NC junction in HIV-1, SLVmac251 and Pr72Gag(MLV-HIV) suggested that a higher hydrophilic character of the CA region immediately upstream to the HIV-1 CA-SP1 junction, as occurred in Pr72Gag(MLV-HIV), correlated with a lower DSB sensitivity.

Statistical shape analysis of large datasets based diffeomorphic iterative centroids PDF available through Get Fulltext Research

Cury, Claire Glaunés, Joan Roberto Toro Chupin, Marie Shumann, Gunter Frouin, Vincent Poline, Jean-Baptiste Colliot, Olivier

Published in Frontiers in Neuroscience

In this paper, we propose an approach for template-based shape analysis of large datasets, using diffeomorphic centroids as atlas shapes. Diffeomorphic centroid methods fit in the Large Deformation Diffeomorphic Metric Mapping (LDDMM) framework and use kernel metrics on currents to quantify surface dissimilarities. The statistical analysis is based...

Genetic characterization and therapeutic targeting of MYC translocated pediatric T-cell acute lymphoblastic leukemia PDF available through Get Fulltext Research

Milani, Gloria Durinck, Kaat Matthijssens, Filip Peirs, Sofie Pieters, Tim Reunes, Lindy Lintermans, Béatrice Vandamme, Niels Lammens, Tim Li, Yunlei ...

Published in British Journal of Haematology

Computational pan-genomics: status, promises and challenges

Marschall, Tobias Marz, Manja Abeel, Thomas Dijkstra, Louis Dutilh, Bas E. Ghaffaari, Ali Kersey, Paul Kloosterman, Wigard P. Makinen, Veli Novak, Adam M. ...

Published in Briefings in Bioinformatics

Many disciplines, from human genetics and oncology to plant breeding, microbiology and virology, commonly face the challenge of analyzing rapidly increasing numbers of genomes. In case of Homo sapiens, the number of sequenced genomes will approach hundreds of thousands in the next few years. Simply scaling up established bioinformatics pipelines wi...

Plasticité des cellules intestinales : nature et fonction

Le Gall, Maude André Bado Le Beyec, Johanne

Published in Cahiers de Nutrition et de Diététique

La plasticité d'un matériau est sa propriété à modifier sa forme sous l'effet d'une action et à la conserver à l'arrêt de cette action. Par analogie, la plasticité neuronale décrit comment des neurones s'étendent, se rétractent ou se réorganisent en fonction de l'activité des synapses et des neurones qu'ils rencontrent et comment au niveau des syna...

Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons PDF available through Get Fulltext Research

Gard, Chris Gonzalez Curto, Gloria El-Mokhtar, Youcef Chollet, Elodie Duval, Nathalie Auzié, Valentine Auradé, Frédéric Vigier, Lisa Relaix, Frédéric Alessandra Pierani ...

Published in Developmental Biology

Transcription factors are key orchestrators of the emergence of neuronal diversity within the developing spinal cord. As such, the two paralogous proteins Pax3 and Pax7 regulate the specification of progenitor cells within the intermediate neural tube, by defining a neat segregation between those fated to form motor circuits and those involved in t...

Enhanced Abventricular Proliferation Compensates Cell Death in the Embryonic Cerebral Cortex

Freret-Hodara, Betty Cui, Yi Griveau, Amélie Vigier, Lisa Arai, Yoko Touboul, Jonathan Alessandra Pierani

Published in Cerebral Cortex

Loss of neurons in the neocortex is generally thought to result in a final reduction of cerebral volume. Yet, little is known on how the developing cerebral cortex copes with death of early-born neurons. Here, we tackled this issue by taking advantage of a transgenic mouse model in which, from early embryonic stages to mid-corticogenesis, abundant ...

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